منابع مشابه
Methylation Status of SMG1 Gene Promoter in Multiple Myeloma
Background: Epigenetic modifications, such as methylation can occur in multiple myeloma. SMG1is an important gene involved in cell growth which defect in methylation of its promoter leads to reduction of cell apoptosis and uncontrolled proliferation. In this study, we identified the methylation status of the SMG1 gene promoter in patients with multiple myeloma. Methods: Methylation status of S...
متن کاملp53 mutations in multiple myeloma.
Correspondence p53 gene mutations in multiple myeloma We were interested in the article by Owen et al on p53 gene mutations in multiple myeloma.' They had studied the p53 exons 5-9 by PCR-SSCP and they found only one p53 mutation among 36 DNA samples from 31 patients with multiple myeloma. They concluded that p53 mutations are rare and confined to end stage leukaemic forms of the disease. We al...
متن کاملPresence of a p53 gene deletion in patients with multiple myeloma predicts for short survival after conventional-dose chemotherapy.
In multiple myeloma (MM), previous studies showed that mutations of the p53 gene are rare events in patients with newly diagnosed disease, but it is not known whether deletions of p53 are of any significance in MM. To address this question, we used interphase fluorescence in situ hybridization (FISH) with a DNA probe specific for the p53 locus at 17p13 and investigated bone marrow plasma cells ...
متن کاملTargeting p53 by small molecule p53 activators in multiple myeloma
For the past three decades of research, p53 has been identified as one of the most targetable molecules for developing anticancer treatments. This tumor suppressor protein is involved in apoptosis, cell cycle arrest and senescence. Impairment of p53 function in tumors occurs either as a result of mutations in the TP53 gene itself or the abrogation of signaling pathways regulating p53 that are r...
متن کاملMultiple Myeloma Update
This literature review presents the most recent developments in the management of multiple myeloma, which is characterized by the presence of abnormal plasma cells (myeloma cells) that accumulate into the bone marrow. Aspects related to pathophysiology, clinical manifestations, laboratory, study and treatment are described. These pieces of information are necessary to accomplish a better ...
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ژورنال
عنوان ژورنال: Revista Brasileira de Hematologia e Hemoterapia
سال: 2003
ISSN: 1516-8484
DOI: 10.1590/s1516-84842003000200014